Investigation of Porosity in the Pastilles

Many different types of controlled dosage forms have been developed to improve clinical efficiency of drug and patient compliance. In vivo performance of these dosage forms, however, depends greatly on their physical and structural properties, and consequently on their drug release mechanisms and its kinetics. A solid complex (matrix) mostly produced by tableting techniques are commonly used in pharmaceutical industries in order to retard the drug dissolution rate. The solid complex is, however, still not optimal since there are problems such as instability of tablet, selection of binder and excipient (additive). Under compressing pressure drug crystals agglomerate, thereby porosity is entrapped in the solid complex. Some researchers ([HOG02], [PAU03], [WES98]) already investigated the entrapment of porosity in the tablets, because it is an important parameters concerning bioavailability and quality of tablets.